




º¸ÀüÀ¯ÀüÇÐ/º¸Àü»ý¹°ÇÐ ÀÚ·á 




Name 

¿î¿µÀÚ 
20050214 14:41:05  Hit : 11658  Vote : 1514 




Subject 

[ÀÚ·á¿ä¾à¹®] Comparative evaluation of a new effective population size estimator based on approximate bayesian computation 




Genetics. 2004 Jun;167(2):97788.
Related Articles, Links
Comparative evaluation of a new effective population size estimator based on approximate bayesian computation.
Tallmon DA, Luikart G, Beaumont MA.
Laboratoire d'Ecologie Alpine, UMR Centre National de la Recherche Scientifique 5553, Universite Joseph Fourier, F38041 BP 53 Cedex 09, Grenoble, France. dtallmon42@yahoo.com
We describe and evaluate a new estimator of the effective population size (N(e)), a critical parameter in evolutionary and conservation biology. This new "SummStat" N(e) estimator is based upon the use of summary statistics in an approximate Bayesian computation framework to infer N(e). Simulations of a WrightFisher population with known N(e) show that the SummStat estimator is useful across a realistic range of individuals and loci sampled, generations between samples, and N(e) values. We also address the paucity of information about the relative performance of N(e) estimators by comparing the SummStat estimator to two recently developed likelihoodbased estimators and a traditional momentbased estimator. The SummStat estimator is the least biased of the four estimators compared. In 32 of 36 parameter combinations investigated using initial allele frequencies drawn from a Dirichlet distribution, it has the lowest bias. The relative mean square error (RMSE) of the SummStat estimator was generally intermediate to the others. All of the estimators had RMSE > 1 when small samples (n = 20, five loci) were collected a generation apart. In contrast, when samples were separated by three or more generations and N(e) < or = 50, the SummStat and likelihoodbased estimators all had greatly reduced RMSE. Under the conditions simulated, SummStat confidence intervals were more conservative than the likelihoodbased estimators and more likely to include true N(e). The greatest strength of the SummStat estimator is its flexible structure. This flexibility allows it to incorporate any potentially informative summary statistic from population genetic data.
PMID: 15238546 [PubMed  in process] 


