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2006-10-16 14:24:29 | Hit : 25921 | Vote : 9331

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[자료] A tutorial on statistical methods for population association studies

A tutorial on statistical methods for population association studies

David J.Balding

Abstract |

Although genetic association studies have been with us for many years, even for the simplest analyses there is little consensus on the most appropriate statistical procedures. Here I give an overview of statistical approaches to population association studies, including
preliminary analyses (Hardy –Weinberg equilibrium testing, inference of phase and missing data, and SNP tagging), and single-SNP and multipoint tests for association. My goal is to outline the key methods with a brief discussion of problems (population structure and multiple testing), avenues for solutions and some ongoing developments.

http://www.nature.com/nrg/journal/v7/n10/pdf/nrg1916.pdf

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