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2005-12-09 11:33:53 | Hit : 26582 | Vote : 9394

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[자료] Inbreeding Depressing and Male Survivorship in Drosophila: Implications for Senescence Theory

Genetics. 2005 Oct 3; [Epub ahead of print] Related Articles, Links

Inbreeding Depressing and Male Survivorship in Drosophila: Implications for Senescence Theory.

Swindell WR, Bouzat JL.

Bowling Green State University.

The extent to which inbreeding depression affects longevity and patterns of survivorship is an important issue from several research perspectives, including evolutionary biology, conservation biology, and the genetic analysis of quantitative traits. However, few previous inbreeding depression studies have considered longevity as a focal life history trait. We maintained laboratory populations of Drosophila melanogaster at census population sizes of two and ten male-female pairs for up to 66 generations, and performed repeated assays of male survivorship throughout this time period. On average, significant levels of inbreeding depression were observed for median life span and age-specific mortality. For age-specific mortality, the severity of inbreeding depression increased over the life span. We found that a baseline inbreeding load of 0.307 lethal equivalents per gamete affected age-specific mortality, and that this value increased at a rate of 0.046 per day of the life span. With respect to some survivorship parameters, the differentiation of lineages was non-linear with respect to the inbreeding coefficient, which suggested that non-additive genetic variation contributed to variation among lineages. These findings provide insights into the genetic basis of longevity as a quantitative trait, and have implications regarding the mutation accumulation evolutionary explanation of senescence.

PMID: 16204222 [PubMed - as supplied by publisher]

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