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  운영자 2007-05-28 11:05:50 | Hit : 10305 | Vote : 2620
Subject   [자료] Phylogeny of North American Powassan virus
Journal of General Virology (2001), 82, 1657-1665.
© 2001 Society for General Microbiology

Animal: RNA Viruses

Phylogeny of North American Powassan virus

Gregory D. Ebel1, Andrew Spielman1 and Sam R. Telford, III1

Laboratory of Public Health Entomology, Department of Immunology and Infectious Diseases, Harvard School of Public Health, 665 Huntington Ave, Boston, MA 02115, USA1

Authors for correspondence: Gregory Ebel (Present address: Arbovirus Unit of the Wadsworth Center’s Griffin Laboratory, 5668 State Farm Rd., Slingerlands, NY 12159, USA; Fax +1 518 869 4530; e-mail ebel@wadsworth.org) and Sam Telford (Fax +1 617 432 1796; e-mail stelford@hsph.harvard.edu).

To determine whether Powassan virus (POW) and deer tick virus (DTV) constitute distinct flaviviral populations transmitted by ixodid ticks in North America, we analysed diverse nucleotide sequences from 16 strains of these viruses. Two distinct genetic lineages are evident, which may be defined by geographical and host associations. The nucleotide and amino acid sequences of lineage one (comprising New York and Canadian POW isolates) are highly conserved across time and space, but those of lineage two (comprising isolates from deer ticks and a fox) are more variable. The divergence between lineages is much greater than the variation within either lineage, and lineage two appears to be more diverse genetically than is lineage one. Application of McDonald–Kreitman tests to the sequences of these strains indicates that adaptive evolution of the envelope protein separates lineage one from lineage two. The two POW lineages circulating in North America possess a pattern of genetic diversity suggesting that they comprise distinct subtypes that may perpetuate in separate enzootic cycles.

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