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  운영자 2007-02-12 18:50:53 | Hit : 8373 | Vote : 2422
Subject   [자료] Unifying the spatial population dynamics and molecular evolution of epidemic rabies virus
Proc Natl Acad Sci U S A. 2005 August 23; 102(34): 12107–12111.
Published online 2005 August 15. doi: 10.1073/pnas.0500057102.
Copyright © 2005, The National Academy of Sciences


Unifying the spatial population dynamics and molecular evolution of epidemic rabies virus

Leslie A. Real,†‡ J. Caroline Henderson,† Roman Biek,† Jennifer Snaman,† Tracy Lambert Jack,§ James E. Childs,† Eli Stahl,†¶ Lance Waller, Rowland Tinline,†† and Susan Nadin-Davis‡‡

†Department of Biology and Center for Disease Ecology, 1510 Clifton Road, Emory University, Atlanta, GA 30322; Departments of §Epidemiology and Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA 30322; ††Queen's Geographic Information Systems Lab, Queen's University, Kingston, ON, Canada K7L 3N6; and ‡‡Animal Disease Research Institute, 3851 Fallowfield Road, Ottawa, ON, Canada K2H 8P9

‡ To whom correspondence should be addressed. E-mail: lreal@emory.edu.
¶Present address: Department of Biology, University of Massachusetts Dartmouth, North Dartmouth, MA 02747.
Edited by Simon A. Levin, Princeton University, Princeton, NJ, and approved June 24, 2005

Received January 5, 2005.


Infectious disease emergence is under the simultaneous influence of both genetic and ecological factors. Yet, we lack a general framework for linking ecological dynamics of infectious disease with underlying molecular and evolutionary change. As a model, we illustrate the linkage between ecological and evolutionary dynamics in rabies virus during its epidemic expansion into eastern and southern Ontario. We characterized the phylogeographic relationships among 83 isolates of fox rabies virus variant using nucleotide sequences from the glycoprotein-encoding glycoprotein gene. The fox rabies virus variant descended as an irregular wave with two arms invading from northern Ontario into southern Ontario over the 1980s and 1990s. Correlations between genetic and geographic distance suggest an isolation by distance population structure for the virus. The divergence among viral lineages since the most recent common ancestor correlates with position along the advancing wave front with more divergent lineages near the origin of the epidemic. Based on divergence from the most recent common ancestor, the regional population can be partitioned into two subpopulations, each corresponding to an arm of the advancing wave. Subpopulation A (southern Ontario) showed reduced isolation by distance relative to subpopulation B (eastern Ontario). The temporal dynamics of subpopulation A suggests that the subregional viral population may have undergone several smaller waves that reduced isolation by distance. The use of integrated approaches, such as the geographical analysis of sequence variants, coupled with information on spatial dynamics will become indispensable aids in understanding patterns of disease emergence.

Keywords: infectious disease, isolation by distance, landscape genetics


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