::: Welcome to Conservation Genome Resource Bank for Korean Wildlife :::
 
17_c.gif 문헌정보
17_c.gif 야생동물관련 자료 및 소식
17_c.gif 종정보
17_c.gif 보전유전학/보전생물학 자료
17_c.gif 야생동물의학 소식 및 자료
  - 천연기념물의 대상
sound.gif 갤러리
sound.gif 자유게시판 (옛날 게시판)
sound.gif 관련사이트
sound.gif 자료실
sound.gif 찾아오시는 길
야생동물의학 소식 및 자료

View Article
Name
  운영자 2007-02-12 18:50:53 | Hit : 8373 | Vote : 2422
Subject   [자료] Unifying the spatial population dynamics and molecular evolution of epidemic rabies virus
Proc Natl Acad Sci U S A. 2005 August 23; 102(34): 12107–12111.
Published online 2005 August 15. doi: 10.1073/pnas.0500057102.
Copyright © 2005, The National Academy of Sciences

Evolution

Unifying the spatial population dynamics and molecular evolution of epidemic rabies virus

Leslie A. Real,†‡ J. Caroline Henderson,† Roman Biek,† Jennifer Snaman,† Tracy Lambert Jack,§ James E. Childs,† Eli Stahl,†¶ Lance Waller, Rowland Tinline,†† and Susan Nadin-Davis‡‡

†Department of Biology and Center for Disease Ecology, 1510 Clifton Road, Emory University, Atlanta, GA 30322; Departments of §Epidemiology and Biostatistics, Rollins School of Public Health, Emory University, Atlanta, GA 30322; ††Queen's Geographic Information Systems Lab, Queen's University, Kingston, ON, Canada K7L 3N6; and ‡‡Animal Disease Research Institute, 3851 Fallowfield Road, Ottawa, ON, Canada K2H 8P9

‡ To whom correspondence should be addressed. E-mail: lreal@emory.edu.
¶Present address: Department of Biology, University of Massachusetts Dartmouth, North Dartmouth, MA 02747.
Edited by Simon A. Levin, Princeton University, Princeton, NJ, and approved June 24, 2005

Received January 5, 2005.

Abstract

Infectious disease emergence is under the simultaneous influence of both genetic and ecological factors. Yet, we lack a general framework for linking ecological dynamics of infectious disease with underlying molecular and evolutionary change. As a model, we illustrate the linkage between ecological and evolutionary dynamics in rabies virus during its epidemic expansion into eastern and southern Ontario. We characterized the phylogeographic relationships among 83 isolates of fox rabies virus variant using nucleotide sequences from the glycoprotein-encoding glycoprotein gene. The fox rabies virus variant descended as an irregular wave with two arms invading from northern Ontario into southern Ontario over the 1980s and 1990s. Correlations between genetic and geographic distance suggest an isolation by distance population structure for the virus. The divergence among viral lineages since the most recent common ancestor correlates with position along the advancing wave front with more divergent lineages near the origin of the epidemic. Based on divergence from the most recent common ancestor, the regional population can be partitioned into two subpopulations, each corresponding to an arm of the advancing wave. Subpopulation A (southern Ontario) showed reduced isolation by distance relative to subpopulation B (eastern Ontario). The temporal dynamics of subpopulation A suggests that the subregional viral population may have undergone several smaller waves that reduced isolation by distance. The use of integrated approaches, such as the geographical analysis of sequence variants, coupled with information on spatial dynamics will become indispensable aids in understanding patterns of disease emergence.


Keywords: infectious disease, isolation by distance, landscape genetics


http://www.pubmedcentral.nih.gov/articlerender.fcgi?tool=pubmed&pubmedid=16103358

 Prev   [자료] Wildlife Veterinarian, Conservation and Public Health
운영자
  2007/02/19 
 Next   [자료] Rabies and other lyssavirus diseases
운영자
  2007/02/05 


Copyright 1999-2020 Zeroboard / skin by daerew
151-742 서울특별시 관악구 신림9동 산56-1 서울대학교 수의과대학 85동 802호
Tel 02-888-2744, Fax 02-888-2754, E-mail cgrb@cgrb.org

Copyright © 2002-2004 CGRB All Rights Reserved